The Jackson Laboratory Hearing Research Program

The fairly common occurrence of hearing-loss or deafness in both humans and mice, and the anatomical and functional similarities of their inner ears, attest to the potential of mice as models to study hereditary hearing loss. Hundreds of standard inbred, recombinant inbred, and congenic strains are maintained at The Jackson Laboratory, as well as hundreds of inbred strains with spontaneous or induced mutations. To assess hearing impairment in inbred and mutant strains of mice we measure auditory-evoked brainstem response (ABR) thresholds.

 

Inbred strains

 

Listed alphabetically by strain designation.

Here we present ABR thresholds of mice from a large number of inbred strains that were tested at different ages. These data were first  published in Hear Res 1999 Apr;130(1-2):94-107

 

Mouse mutations

 

Listed chronologically (most recent first)

 Listed alphabetically (according to gene symbol)

Here we provide links to publications and descriptions of new mutations with hearing impairment or vestibular dysfunction that were discovered and characterized  by our research program at The Jackson Laboratory.

 

* The original screening program was supported by National Institute on Deafness and other Communication Disorders, contract grant DC62108. Our current research program is supported by R01 grants DC005827 and DC004301.

Content maintained by Ken Johnson (ken.johnson@jax.org).