Age-related hearing loss genesi in mice

Table 1. Genetic factors that contribute to age-related hearing loss in inbred mouse strains

AHL locus (gene)

Chr

Most likely location

Mapping methods *

Known strains with susceptibility allele

Known strains with resistance allele

References

ahl (Cdh23)

10

30 cM

backcross, strain haplotypes

Many

Many

[2,5,7]

ahl2

5

40-55 cM

backcross

NOD/LtJ

C57BL/6J, CAST/Ei

[3]

ahl3

17

33-35 cM

CS strains, backcross

C57BL/6J

MSM (molossinus)

[6, 9]

ahl4

10

 65-75 cM

RI, CS strains, backcross

A/J

C57BL/6J, CAST/Ei

       [10]

ahl5

10

35-42 cM

backcross, intercross

Black Swiss

CAST/Ei

[1]

ahl6

18

38-44 cM

backcross

Black Swiss

CAST/Ei

[1]

ahl7

reserved

        

ahl8

11

 70-80 cM

RI strains, backcross

DBA/2J

C57BL/6J

[11]

Phl1

17

5-20 cM

 intercross

101/H

MAI/Pas, MBT/Pas

[8]

Phl2

10

30-40 cM

 intercross

101/H

MAI/Pas, MBT/Pas

[8]

mtDNA(mt-Tr)

mitochondria

backcross

A/J

  

[4]

* CS= chromosome substitution; RI = recombinant inbred

[1]  Drayton, M. and Noben-Trauth, K., Mapping quantitative trait loci for hearing loss in Black Swiss mice, Hear Res (2006) 212: 128-139.

[2]  Johnson, K.R., Erway, L.C., Cook, S.A., Willott, J.F. and Zheng, Q.Y., A major gene affecting age-related hearing loss in C57BL/6J mice, Hear Res (1997) 114: 83-92.

[3]  Johnson, K.R. and Zheng, Q.Y., Ahl2, a second locus affecting age-related hearing loss in mice, Genomics (2002) 80: 461-464.

[4]  Johnson, K.R., Zheng, Q.Y., Bykhovskaya, Y., Spirina, O. and Fischel-Ghodsian, N., A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice, Nat Genet (2001) 27: 191-194.

[5]  Johnson, K.R., Zheng, Q.Y. and Erway, L.C., A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice., Genomics (2000) 70: 171-180.

[6]  Nemoto, M., Morita, Y., Mishima, Y., Takahashi, S., Nomura, T., Ushiki, T., Shiroishi, T., Kikkawa, Y., Yonekawa, H. and Kominami, R., Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss, Biochem Biophys Res Commun (2004) 324: 1283-1288.

[7]  Noben-Trauth, K., Zheng, Q.Y. and Johnson, K.R., Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss, Nat Genet (2003) 35: 21-23.

[8]  Mashimo, T., Erven, A.E., Spiden, S.L., Guenet, J.L. and Steel, K.P., Two Quantitative trait loci affecting progressive hearing loss in 101/H mice, Mamm Genome (2006) 17:841-850.

[9] Morita, Y., Hirokawa, S., Kikkawa, Y., Nomura, T., Yonekawa, H., Shiroishi, T., Takahashi, S., and Kominami, R., Fine mapping of Ahl3 affecting both age-related and noise-induced hearing loss. Bioch Biophys Res Commun (2007) 355: 117-121.

[10] Zheng, Q.Y., Ding, D., Salvi, R.J., and Johnson, K.R. A locus on distal Chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice. Neurobiol Aging (2008) [Epub ahead of print]       

[11]  Johnson, K.R., Longo-Guess, C., Gagnon, L.H., Yu, H., and Zheng, Q.Y. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23<ahl> underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics (2008) 92: 219-225.